Structural and Functional Characterization of the ABCC6 Transporter in Hepatic Cells: Role on PXE,Cancer Therapy and Drug Resistance

Pseudoxanthoma elasticum (PXE) is a complex autosomal recessive disease caused by mutations of ABCC6 transporter and characterized by ectopic mineralization of soft connective tissues. Compared to the other ABC transporters, very few studies are available to explain the structural components and working of a full ABCC6 transporter, which may provide some idea about its physiological role in humans. Some studies suggest that mutations of ABCC6 in the liver lead to a decrease in some circulating factor and indicate that PXE is a metabolic disease. It has been reported that ABCC6 mediates the efflux of ATP, which is hydrolyzed in PPi and AMP; in the extracellular milieu, PPi gives potent anti-mineralization effect, whereas AMP is hydrolyzed to Pi and adenosine which affects some cellular properties by modulating the purinergic pathway. Structural and functional studies have demonstrated that silencing or inhibition of ABCC6 with probenecid changed the expression of several genes and proteins such as NT5E and TNAP, as well as Lamin, and CDK1, which are involved in cell motility and cell cycle. Furthermore, a change in cytoskeleton rearrangement and decreased motility of HepG2 cells makes ABCC6 a potential target for anti-cancer therapy. Collectively, these findings suggested that ABCC6 transporter performs functions that modify both the external and internal compartments of the cells.     

基于C++ Builder的串口通信程序实现方法

在工业控制领域,计算机经常通过串口实现与单片机、DSP、PLC等的通信,并被广泛应用。文章叙述了在C++ Builder 6环境下串口通信的3种实现方法,并着重介绍了Windows的API通信函数。     

煤层地质条件的开采工艺性评价软件研制及其应用

在煤层地质条件的开采工艺性评价的基础上，分析了评价结构和指标量化方法，建立了煤层开采工艺性评价的模糊数学模型重点介绍了软件研制的基本思想和技术途径通过调查获取了大量矿井地质、开采资料，并采用该软件进行评价，初步获得了现阶段我国缓倾斜、倾斜煤层开采工艺选择的客观判据，提出了矿井地质条件开采工艺性分类方案为进一步建立全国煤炭开采评价体系提供了先进的技术手段     

高岭土矿超细粉体的制备及表面改性研究

以江西宜春某矿山的高岭土为原料,研究超细高岭土粉体的制备方法和表面有机改性的较佳工艺条件.试验证明,所制得的改性高岭土粉体的有效活性指数达86.4%,经X衍射等分析,表明铝酸酯、钛酸酯复配偶联剂对高岭土表面不仅有较强键能的化学吸附,同时还存在一定的物理吸附.     

基于EVT的GPS RTK接收机研制

本文介绍了GPSRTK接收机的主要结构及其通讯功能 ,重点阐述WindowsCE编程的主要特点和编制接收机程序的关键技术。论证了运行WindowsCE的PDA结合GPSOEM板可以开发性能优越的GPSRTK接收机的可行性     

基于Visual C＋＋的水声目标数据库设计

针对水声目标实测数据量庞大,LOFAR和DEMON分析计算量大的问题,设计了一个基于Visual C＋＋6．0的数据库管理系统。管理系统通过ADO接口实现与SQL Server 2005数据库管理程序的数据交换,保证了数据稳定存储和高效传输。通过内存映射文件技术,实现了对大数据文件的快速读取。采用CPU与GPU并行计算进行了LO-FAR和DEMON分析,实现了LOFAR和DEMON谱图的实时显示。整个数据库管理系统操作简洁高效,可靠性高,具有广泛的实际应用价值。     

基于Lab Windows/CVI的GPIB虚拟仪器的设计

利用Lab windows/CVI的GPIB虚拟仪器远程控制系统,由FSP频谱分析仪、信号发生器、功率放大器等仪器组成,并通过GPIB总线与主控计算机相连.主控计算机内安装IEEE488标准接口卡,通过软件可对各测控设备实现远控和自动或半自动操作,同时对重要数据进行分析和储存.     

Software measure in cyber-attacks on production control system

The likelihood of cyber-attacks against information systems and related production control systems has increased. In order to lower the risk of cyber-attacks, OS makers release timely security updates. However, the amount of time that is available for applying patches is limited on production control systems and the possibility of side effects is a concern. Therefore, we focused on the patch application cycle and the period of pretest, and proposed optimal OS measures for production control systems. We presented the method for quantifying the risk of cyber-attacks on production control systems due to security patches not being applied and for expressing the risk as a monetary amount. This method was also proposed for deriving the patch application cycle, the number of applications, and the optimum test duration. We concluded that this method help to understand the patch management and related security measure and to protect production control systems from cyber-attacks.     

基于Windows7平台的高校计算机机房改造与实施

以郧阳师范高等专科学校计算机中心机房为例,介绍了基于Windows 7平台下机房建设改造过程中的硬件、软件及网络设备的方案选用,及工程实施过程中需要注意的问题和实践经验。     

国产聚苯乙烯在窗口膜生产中的应用与实施

简要介绍BOPS国产化原料在环保绿色窗口膜生产中的应用与实施，阐述聚苯乙烯（BOPS）料粒在薄膜生产中使用的特点，以及其良好的发展前景，重点论述该产品生产过程中的关键技术。